COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protectionArticle Published on 2022-10-152022-11-15 Journal: Journal of Biomedical Science [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] adverse effects analyzed biological basis booster clinical impact COVID-19 COVID-19 vaccine COVID-19 vaccines death effective Effectiveness immune correlate Immunity knowledge pandemic potential mechanism provided public health reduced regimen researcher risk SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants severe adverse events the SARS-CoV-2 virus Vaccine Vaccines Variant. virus with COVID-19 [DOI] 10.1186/s12929-022-00853-8 PMC 바로가기
The next frontier in vaccine design: blending immune correlates of protection into rational vaccine designReview Published on 2022-10-012022-10-05 Journal: Current opinion in immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] accelerate accelerated antibody Antibody binding canonical Community Complete death embedding immune correlate Immune profile Immunity immunological lack neutralization pathogen populations protective vaccines question raised severe disease the vaccine to define Vaccine Vaccine design Vaccine development Vaccines variants of concern Viral variants waned [DOI] 10.1016/j.coi.2022.102234 [Article Type] Review
COVID-19 outbreak in vaccinated patients from a haemodialysis unit: antibody titres as a marker of protection from infection혈액 투석실에서 예방 접종을 받은 환자의 COVID-19 발생: 감염으로부터 보호하는 지표로서의 항체 역가Article Published on 2022-06-232022-09-11 Journal: Nephrology, dialysis, transplantation : official p [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Alpha variant anti-S anti-S IgG Anti-spike Antibody titre BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 vaccine Casirivimab cause Clinical data Combination confidence interval coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection COVID-19 outbreak dialysis dialysis room Haemodialysis humoral Humoral response identify IgG Imdevimab immune correlate immune correlates Immunoglobulin Immunoglobulin G Immunosuppression increased risk Infection interquartile range IQR marker monoclonal antibodies monoclonal antibodies. monoclonal antibody mRNA vaccination multivariable analysis neutralization Odds ratio outbreak Patient patients prevented recorded reduced respiratory SARS-CoV-2 SARS-COV-2 infection serological response severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 severe disease the patient titre treated uninfected vaccination Vaccines variant were infected with COVID-19 [DOI] 10.1093/ndt/gfac016 PMC 바로가기 [Article Type] Article
The influence of time on the sensitivity of SARS-CoV-2 serological testingSARS-CoV-2 혈청 검사의 민감도에 대한 시간의 영향Article Published on 2022-06-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI Abbott anti-SARS-CoV-2 antibodies Antibody titer Antibody titers approach assays best booster vaccination collected Course days post infection demonstrated detect detectable diagnostic diagnostic sensitivity Elecsy evaluated Evidence evidence of follow-up period immune correlate immune correlates infected with SARS-CoV-2 Infection limitation long-lasting median Meso Scale Discovery MSD natural infection Neutralizing no evidence of nucleoprotein occurred Patient performed positive Probability proportion provide Quantitative Roche SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody sensitive sensitivity serological test Serological testing Serological tests shown spike Spike protein Support survival survival time symptom onset the spike protein therapy time-to-event analysis Treatment [DOI] 10.1038/s41598-022-14351-2 PMC 바로가기 [Article Type] Article
Fighting Fire with Fire: Immunogenicity of Viral Vectored Vaccines against COVID-19화재로 화재 퇴치 : Covid-19에 대한 바이러스 성 벡터 백신의 면역 원성Review Published on 2022-02-122022-09-01 Journal: Viruses [Category] COVID19(2023년), Fulltext, MERS, SARS, 비임상, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody approved breadth breath caused cellular Clinical studies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 distribution effective elicited Fighting fire global pandemic globe humoral immune correlate immune correlates immune response immune responses immunogenicity innate immune response limitation mass vaccination morbidity Mortality offer provide rationale reduce regimens respiratory Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus T cells Transmission vaccination Vaccine Viral viral vectored vaccine viral vectored vaccines viral vectors [DOI] 10.3390/v14020380 PMC 바로가기 [Article Type] Review
AutoPlate: Rapid Dose-Response Curve Analysis for Biological AssaysAutoPlate: 생물학적 분석을 위한 신속한 용량 반응 곡선 분석Immunology Published on 2022-02-102022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accelerate analysed Analysis Biological biological assay COVID-19 Curve Data analysis develop Dose-response effective ELLA example immune correlate immunoassays IMPROVE Influenza Laboratory pseudotype pseudotype neutralization pseudovirus Rapid Safe SARS-C0V-2 SARS-CoV-2 Scientific community time-consuming Vaccine virus [DOI] 10.3389/fimmu.2021.681636 PMC 바로가기 [Article Type] Immunology
Sustained Antibody-Dependent NK Cell Functions in Mild COVID-19 Outpatients During Convalescence회복기 동안 경증 COVID-19 외래 환자의 지속적인 항체 의존성 NK 세포 기능Immunology Published on 2022-02-072022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome addition Anti-spike anti-spike antibody anti-viral response antibody blood sample Cell characterized Cohort collected contribute convalescence coronavirus coronavirus disease correlated COVID-19 COVID-19 outpatients COVID19 defined disease Fc-effector functions female function heterogeneous humoral Humoral response identify IgA IgG titers immune correlate male natural killer neutralization NK cells activity Outpatient outpatients pandemic profile researcher response responses SARS-CoV-2 severity spike (S) glycoprotein Spike protein sustained the SARS-CoV-2 Virus neutralization while [DOI] 10.3389/fimmu.2022.796481 PMC 바로가기 [Article Type] Immunology
Standardization of two SARS-CoV-2 serology assays to the WHO 20/136 human standard reference materialWHO 20/136 인간 표준 참조 물질에 대한 2개의 SARS-CoV-2 혈청학 분석 표준화Article Published on 2022-02-012022-09-12 Journal: Journal of virological methods [Category] Coronavirus, COVID19(2023년), MERS, SARS, 진단, [키워드] Analyzer antibody Antigen assigned Atellica IM Analyzer automated binding antibody unit calibrated COVID-19 cut-off Efficacy help immune correlate Immunoglobulin index material RBD RBD IgG reference SARS-CoV-2 serology assay serology assays Serology reference material Standard standard reference the WHO Total Vaccine WHO WHO 20/136. [DOI] 10.1016/j.jviromet.2021.114430 PMC 바로가기 [Article Type] Article
Protocol for SARS-CoV-2 post-vaccine surveillance study in Australian adults and children with cancer: an observational study of safety and serological and immunological response to SARS-CoV-2 vaccination (SerOzNET)SARS-COV-2 호주 성인 및 암 소아에서의 산후 감시 연구 프로토콜 : SARS-COV-2 백신 접종 (Seroznet)에 대한 안전 및 혈청 학적 및 면역 학적 반응에 대한 관찰 연구 (Seroznet)Study Protocol Published on 2022-01-202022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 변종, 임상, [키워드] acceptability adverse event adverse events allergy Analysis Blood Cancer Cancer patients Characteristics Chemotherapy children clinical clinical trial clinical trials cohorts collected commenced comparable condition controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 vaccinations COVID-19 vaccine COVID-19 vaccines disease manifestation effective enrolled exploration FIVE haematological malignancy healthy healthy control healthy controls HM patient HM patients hypogammaglobulinaemia Immune checkpoint inhibitor Immune checkpoint inhibitors immune correlate immune correlates immune response Immunity Immunocompromise Immunological response Immunosuppression immunosuppressive condition immunosuppressive conditions incidence Infection less life malignancy morbidity and mortality naïve New observational study organ pandemic coronavirus Patient Patients with cancer peripheral Peripheral blood Polysorbate polysorbate 80 populations Post-vaccine pre-vaccination processed proportion prospective observational study Quality question receiving reducing Registered Registration registry reported required robust SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine Serologic response serologic responses serological serological response severe COVID-19 SOC solid organ supplementary material Surveillance systemic therapy T-cell therapy timepoint Toxicity Treatment Trial unique vaccination Vaccinations Vaccine Vaccine hesitancy vaccine response variants virus were excluded [DOI] 10.1186/s12879-021-07019-1 PMC 바로가기 [Article Type] Study Protocol
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe IndividualsImmunology Published on 2021-11-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] abnormality active infection adaptive immune responses Adults CD8+ T cells Cell comparison convalescent COVID-19 cytokine cytokine profile elevated endothelial growth factor hepatocyte growth factor immune immune correlate immune recovery immune response Immunophenotyping individual Inflammation low-density lymphopenia Mild neutrophil counts Neutrophils NKT non-classical monocyte persistent pro-inflammatory cytokine proportion SARS – CoV – 2 SARS-COV-2 infection severe COVID-19 severely infected patient severity survivor T cells Vascular virus clearance [DOI] 10.3389/fimmu.2021.710217 PMC 바로가기 [Article Type] Immunology